This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
ATPase and the human Na+,K+-ATPase al, a2, and c3 isoforms. The higher conservation betweenATPIAL2and the Na+,K+-ATPase al, a2, and c3 isoforms suggests that ATPJAL2mayencodeafourth Na+,K+-ATPaseaisoform. Expression ofATPIAL2 in Human Tissues. PCRof ran-domlyprimedcDNAsfromhumanbrain,heart,kidney,lung, andskeletal K. Hussain, Z. Ismail, A. Sadikun, and P. Ibrahim, “Bioactive markers based pharmacokinetic evaluation of extracts of a traditional medicinal plant, Piper sarmentosum,” Evidence-Based Complementary and Alternative Medicine. In press. View at: Publisher Site | Google Scholar the H +,K -ATPase activity shows that cibenzoline increases K m value for K without a•ecting Vmax, indicating that this drug inhibits H+,K +-ATPase activity competitively with respect to K . 4 The inhibitory e•ect of H+,K+-ATPase activity by cibenzoline with normal tight gastric vesicles Transmembrane ATPases import many of the metabolites necessary for cell metabolism and export toxins, wastes, and solutes that can hinder cellular processes. An important example is the sodium-potassium exchanger (or Na + /K + ATPase) that maintains the cell membrane potential.And another example is the hydrogen potassium ATPase (H + /K + ATPase or gastric proton pump) that acidifies … Search results for H /K -ATPase at Sigma-Aldrich
Gastric H + /K + ATPase. Main article: Hydrogen potassium ATPase. Animals have a gastric hydrogen potassium ATPase or H + /K + ATPase that belongs to the P-type ATPase family and functions as an electroneutral proton pump. This pump is found in the plasma membrane of cells in the gastric mucosa and functions to acidify the stomach. Acid-related gastric diseases are associated with disorder of digestive tract acidification. The gastric proton pump, H(+),K(+)-ATPase, exports H(+) in exchange for luminal K(+) to generate a highly acidic environment in the stomach, and is a main target for acid suppressants. 09/04/41 · The Na,K-ATPase was purified and reconstituted into single-walled, tight liposomes filled with a reservoir of ATP and Na in which the Na,K-ATPase functions as in cells, that is, the receptor is 06/02/31 · For the Love of Physics - Walter Lewin - May 16, 2011 - Duration: 1:01:26. Lectures by Walter Lewin. They will make you ♥ Physics. Recommended for you ab2866 staining Hydrogen Potassium ATPase Beta/ATP4B in mouse stomach tissue sections by IHC-P (formaldehyde-fixed paraffin-embedded sections). Tissue samples were fixed with formaldehyde and blocked with 4% serum for 30 minutes at 25°C; antigen retrival was by heat mediation in Citrate buffer.
06/02/31 · For the Love of Physics - Walter Lewin - May 16, 2011 - Duration: 1:01:26. Lectures by Walter Lewin. They will make you ♥ Physics. Recommended for you ab2866 staining Hydrogen Potassium ATPase Beta/ATP4B in mouse stomach tissue sections by IHC-P (formaldehyde-fixed paraffin-embedded sections). Tissue samples were fixed with formaldehyde and blocked with 4% serum for 30 minutes at 25°C; antigen retrival was by heat mediation in Citrate buffer. Atpase definition, adenosine triphosphatase: any of several enzymes that catalyze the hydrolysis of ATP to ADP and phosphate. See more. Na + /K +-ATPase α Antibody (H-3) is a high quality monoclonal Na+/K+-ATPase alpha antibody (also designated ATP1A1 antibody or ATPase Na+/K+ transporting subunit alpha 1 antibody) suitable for the detection of the Na+/K+-ATPase alpha protein of mouse, rat and human origin. ATPase Na+/K+ beta 3 Antibody (H00000483-B01P): Novus Biologicals Unusual Roles of Secretory SNARE SYP132 in Plasma Membrane H+- PLOS ONE: Cyclophilin B Interacts with Sodium-Potassium ATPase and The gastric H,K-ATPase in stria vascularis contributes to pH Glucocorticoids Stimulate the Maturation of H,K-ATPase in the 13/12/39 · The gastric proton pump, H +, K +-ATPase (HKA) is a member of P 2-type ATPase family, which is found in the stomach parietal cells.The HKA plays a …
14/01/41 · Among the P-type ATPase family members, the P1- to P3-ATPases are ion transporters, with the most representative being the P2-ATPase family, which includes the sarcoplasmic reticulum Ca 2+ pump (SERCA), Na + /K +-ATPase, and H + /K +-ATPase. The P4-ATPase is the only member that functions as a lipid transporter . http://www.yso.fi/onto/mesh/D017506. Ladda ned detta begrepp: RDF/XML TURTLE JSON-LD TURTLE JSON-LD the H-K-ATPase isoform that is upregulated during K deple-tion and putatively responsible for K reabsorption was achieved by measuring an increase in its mRNA and/or protein level under this specific condition (2, 49, 58). These results prompted many investigators to propose that this transporter 09/02/36 · ABSTRACT. The vacuolar H +-ATPase (V-ATPase) has long been appreciated to function as an electrogenic H + pump. By altering the pH of intracellular compartments, the V-ATPase dictates enzyme activity, governs the dissociation of ligands from receptors and promotes the coupled transport of substrates across membranes, a role often aided by the generation of a transmembrane electrical … 16/07/25 · The Plasma Membrane H +-ATPase. The major ion pumps in plants and fungi are plasma membrane H +-ATPases.Similar pumps are not found in animals, in which the equivalent enzyme is the Na + /K +-ATPase, which in turn is absent from plants.However, both types of pumps are evolutionarily related and belong to the superfamily of P-type ATPases (Axelsen and Palmgren, 1998; Kuhlbrandt, … The sodium and potassium gradients across the plasma membrane are used by animal cells for numerous processes, and the range of demands requires that the responsible ion pump, the Na,K-ATPase, can be fine-tuned to the different cellular needs. Therefore, several isoforms are expressed of each of the three subunits that make a Na,K-ATPase, the alpha, beta and FXYD subunits. This review This brief review addresses the mechanism of acid secretion and the structure-function relationship of the gastric acid pump, the H,K-ATPase. The growth in knowledge of this enzyme in the last few
This section displays by default the canonical protein sequence and upon request all isoforms described in the entry.
09/02/36 · ABSTRACT. The vacuolar H +-ATPase (V-ATPase) has long been appreciated to function as an electrogenic H + pump. By altering the pH of intracellular compartments, the V-ATPase dictates enzyme activity, governs the dissociation of ligands from receptors and promotes the coupled transport of substrates across membranes, a role often aided by the generation of a transmembrane electrical …
